Excellent Radiological Response with Modern Contemporary Proton Beam Therapy in Favorable Molecular Low-Intermediate Grade Oligodendroglioma: A Report of Two Cases

Abstract Radiotherapy (RT) has been a long-standing treatment option for low-grade glioma. Improvements in tumor control and reduced radiation-related toxicity can be attributed to advances neuroimaging as well RT planning delivery techniques. The molecular markers such isocitrate dehydrogenase lpl9q play key role determining which patients will benefit most from combined radiation systemic therapy. We hereby report two cases of favorable low-intermediate grade oligodendroglioma treated with modern proton pencil-beam therapy under high-precision image guidance showing excellent radiological response that is usually not seen conventional photon radiation.